ICMR-NIPCR DoseMate™

Body Surface Area (BSA) Normalization — K_m Factor Method

Note: The dose conversion calculator can be used for the Animal to Human, Human to Animal and Animal to Animal drug dose conversion.

Allometric Scaling — The Three-Way Bridge of Dose Conversion

Select Species & Enter Dose

Converted Dose (mg/kg) = Source Dose (mg/kg) × K_m (Source)K_m (Target)

Select host (source species) K_m —

Dose in host (mg/kg)

Note: This calculator applies the body-surface-area (BSA) normalization method recommended in the US-FDA Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers (CDER, July 2005), using the K_m-factor ratio between source and target species. It is intended as a reference aid for preclinical research planning only and does not substitute for institutional Animal Ethics Committee (IAEC) approval, toxicological judgement, or regulatory review.